What would Socrates have made of normal tension glaucoma?

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Transgenic TBK1 mice have features of normal tension glaucoma.

Duplication of the TBK1 gene is associated with 1-2% of normal tension glaucoma, a common cause of vision loss and blindness that occurs without grossly abnormal intraocular pressure. We generated a transgenic mouse that has one copy of the human TBK1 gene (native promoter and gene structure) incorporated into the mouse genome (Tg-TBK1). Expression of the TBK1 transgene in the retinae of these ...

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Update on Normal Tension Glaucoma

Normal tension glaucoma (NTG) is labelled when typical glaucomatous disc changes, visual field defects and open anterior chamber angles are associated with intraocular pressure (IOP) constantly below 21 mmHg. Chronic low vascular perfusion, Raynaud's phenomenon, migraine, nocturnal systemic hypotension and over-treated systemic hypertension are the main causes of normal tension glaucoma. Goldma...

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Surgery for normal tension glaucoma.

The long term follow up of surgery in normal tension glaucoma is presented. One eye of 18 patients with bilateral progressive disease underwent fistulising surgery. Over follow up periods ranging from 2 to 7 years (50% > or = 5 years) the operated eye showed on average a 30% reduction in intraocular pressure (IOP). This was associated with a marked difference in the rate and number of retinal l...

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Comparison of OCT and HRT Findings Among Normal, Normal Tension Glaucoma, and High Tension Glaucoma

PURPOSE To evaluate the relationship between optic disc and retinal nerve fiber layer (RNFL) measurements obtained with the optical coherence tomography (OCT) and the Heidelberg retina topography (HRT) in normal, normal tension glaucoma (NTG), and high tension glaucoma (HTG). METHODS Normal, NTG and HTG subjects who met inclusion and exclusion criteria were evaluated retrospectively. One hund...

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Uncommon form of normal-tension glaucoma

Aim To present diagnostic particularities, assessment of prognosis, and the need for treatment in a case of normal-tension glaucoma. Methods - presentation of clinical changes and investigations supporting the diagnosis; - careful anamnesis that disclosed new elements, useful for the evaluation of the case. Results after a two-year follow-up period, we can ascertain that the optic atrophy i...

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ژورنال

عنوان ژورنال: British Journal of Ophthalmology

سال: 1995

ISSN: 0007-1161

DOI: 10.1136/bjo.79.5.399